Mdm10 is an ancient eukaryotic porin co-occurring with the ERMES complex
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چکیده
منابع مشابه
Trypanosomal TAC40 constitutes a novel subclass of mitochondrial β-barrel proteins specialized in mitochondrial genome inheritance.
Mitochondria cannot form de novo but require mechanisms allowing their inheritance to daughter cells. In contrast to most other eukaryotes Trypanosoma brucei has a single mitochondrion whose single-unit genome is physically connected to the flagellum. Here we identify a β-barrel mitochondrial outer membrane protein, termed tripartite attachment complex 40 (TAC40), that localizes to this connect...
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The endoplasmic reticulum mitochondria encounter structure (ERMES) tethers the er to mitochondria and contains four structural components: Mmm1, Mdm12, Mdm10, and Mmm2 (Mdm34). The Gem1 protein may play a role in regulating ERMES function. Saccharomyces cerevisiae and Neurospora crassa strains lacking any of Mmm1, Mdm12, or Mdm10 are known to show a variety of phenotypic defects including alter...
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Mitochondria must uptake some phospholipids from the endoplasmic reticulum (ER) for the biogenesis of their membranes. They convert one of these lipids, phosphatidylserine, to phosphatidylethanolamine, which can be re-exported via the ER to all other cellular membranes. The mechanisms underlying these exchanges between ER and mitochondria are poorly understood. Recently, a complex termed ER-mit...
متن کاملSeparating mitochondrial protein assembly and endoplasmic reticulum tethering by selective coupling of Mdm10
The endoplasmic reticulum-mitochondria encounter structure (ERMES) connects the mitochondrial outer membrane with the ER. Multiple functions have been linked to ERMES, including maintenance of mitochondrial morphology, protein assembly and phospholipid homeostasis. Since the mitochondrial distribution and morphology protein Mdm10 is present in both ERMES and the mitochondrial sorting and assemb...
متن کاملBacteria with a eukaryotic touch: a glimpse of ancient evolution?
T he discovery in 1991 by Fuerst and Webb that the chromosome of the bacterium Gemmata obscuriglobus (a member of Planctomycetales) is surrounded by a double membrane, mimicking a eukaryotic nucleus, challenged the traditional prokaryote/eukaryote classification of living organisms based on cell structure (1). Since then, such an unexpected observation has puzzled evolutionists, leading to diff...
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ژورنال
عنوان ژورنال: Biochimica et Biophysica Acta (BBA) - Molecular Cell Research
سال: 2013
ISSN: 0167-4889
DOI: 10.1016/j.bbamcr.2013.10.006